What Does AME Stand For?
AME stands for Apparent Mineralocorticoid Excess
Apparent Mineralocorticoid Excess (AME) is a genetic disorder characterized by an abnormal response to mineralocorticoids, leading to hypertension and electrolyte imbalances. It is primarily caused by mutations in the 11?-hydroxysteroid dehydrogenase type 2 (11?-HSD2) enzyme, which normally protects the mineralocorticoid receptor from activation by cortisol. In individuals with AME, increased cortisol levels can bind to these receptors, mimicking the effects of aldosterone, resulting in sodium retention, potassium loss, and subsequent high blood pressure. Early diagnosis and management are essential to prevent complications associated with long-term hypertension.
Added on 14th April 2008 | Last edited on 16th June 2025 | Edit Acronym