What Does APRIL Stand For?

APRIL stands for A Proliferation Inducing Ligand

APRIL, or A Proliferation Inducing Ligand, is a cytokine belonging to the tumor necrosis factor (TNF) superfamily. It plays a crucial role in immune responses by stimulating the proliferation and survival of certain immune cell types, particularly B cells. APRIL is involved in the regulation of antibody production and is associated with various autoimmune diseases and lymphoid malignancies. Its mechanism of action includes binding to specific receptors, such as BCMA and TACI, influencing cell activation and differentiation within the immune system.