What Does ARNT Stand For?

ARNT stands for Aryl Hydrocarbon Receptor Nuclear Translocator

ARNT, or Aryl Hydrocarbon Receptor Nuclear Translocator, is a transcription factor that plays a critical role in mediating the effects of environmental pollutants, such as dioxins and polycyclic aromatic hydrocarbons, on gene expression. It functions primarily by forming heterodimers with the Aryl Hydrocarbon Receptor (AhR) in response to ligand binding, facilitating the translocation of this complex to the nucleus where it regulates the transcription of various genes involved in xenobiotic metabolism, cell proliferation, and differentiation. Additionally, ARNT is essential for physiological processes, making it a significant focus of research in toxicology and developmental biology.