What Does BER Stand For?
BER stands for Base Excision Repair
Base Excision Repair (BER) is a fundamental cellular mechanism responsible for the repair of damaged DNA caused by oxidation, alkylation, or spontaneous hydrolysis. This process involves the recognition and removal of non-helix-distorting base lesions by specific DNA glycosylases, followed by the incision of the DNA backbone, gap filling by DNA polymerases, and sealing of the strand by DNA ligases. BER plays a critical role in maintaining genomic stability and preventing mutations that can lead to various diseases, including cancer.
Added on 14th April 2008 | Last edited on 16th June 2025 | Edit Acronym