What Does CAK Stand For?

CAK stands for Cdk Activating Kinase

Cdk Activating Kinase (CAK) is a vital regulatory enzyme that activates cyclin-dependent kinases (CDKs) by phosphorylating a specific threonine residue within their T-loop. This activation is crucial for the progression of the cell cycle, enabling the transition between different phases, including G1 to S and G2 to M. CAK plays a significant role in cellular proliferation and has implications in cancer research, as dysregulation of CDKs and their activation can lead to uncontrolled cell division.