What Does CIITA Stand For?

CIITA stands for Class II Transactivator

CIITA, or Class II Transactivator, is a pivotal transcription factor that regulates the expression of major histocompatibility complex (MHC) class II genes. It plays a crucial role in the immune system by facilitating the presentation of antigenic peptides to CD4 T lymphocytes, thereby contributing to the adaptive immune response. CIITA's function is essential for the development and activation of professional antigen-presenting cells, such as dendritic cells, macrophages, and B cells. Understanding CIITA's mechanisms is important for insights into immune regulation and potential therapeutic targets for autoimmune diseases and cancer.