What Does EDHF Stand For?

EDHF stands for Endothelium Derived Hyperpolarizing Factor

Endothelium Derived Hyperpolarizing Factor (EDHF) refers to a group of vasoactive substances produced by the endothelium that induce vasodilation by promoting hyperpolarization of vascular smooth muscle cells. EDHF plays a crucial role in regulating blood flow and vascular tone, particularly in smaller resistance arteries. It contributes to the overall balance of vascular function alongside other endothelial factors such as nitric oxide and prostacyclin. Research indicates that EDHF can involve various signaling mechanisms, including the release of potassium ions and the activation of alternative pathways in response to different stimuli, thereby enhancing endothelial function and cardiovascular health.