What Does ERCC Stand For?

ERCC stands for Excision Repair Cross Complementing

ERCC, or Excision Repair Cross Complementing, refers to a group of genes involved in the DNA repair process, particularly in the repair of UV-induced DNA lesions. This mechanism is crucial for maintaining genomic stability and preventing mutagenesis. The ERCC genes play a key role in nucleotide excision repair (NER), a vital pathway that removes damaged DNA segments and facilitates the synthesis of new, undamaged DNA. Deficiencies in ERCC function are associated with various genetic disorders, including xeroderma pigmentosum and some forms of cancer, highlighting their importance in cellular integrity and repair mechanisms.