What Does FADD Stand For?

FADD stands for Fas Associated Death Domain Protein

FADD, or Fas Associated Death Domain Protein, is a crucial adaptor protein involved in the regulation of apoptosis, the programmed cell death process. It plays a significant role in the extrinsic pathway of apoptosis by linking the Fas receptor to downstream signaling molecules. FADD contains a death domain that facilitates the recruitment of procaspase-8, leading to the activation of caspases and the execution of the cell death program. Its function is essential for maintaining immune homeostasis and preventing the proliferation of potentially harmful cells. Dysregulation of FADD-mediated signaling can contribute to various diseases, including cancer and autoimmune disorders.