What Does FFEM Stand For?

FFEM stands for Freeze Fracture Electron Microscopy

FFEM, or Freeze Fracture Electron Microscopy, is a specialized technique used in electron microscopy to observe the structural features of biological samples at high resolution. This method involves rapidly freezing specimens to preserve their native state, followed by fracturing them to create a cleaved surface. The exposed surfaces are then coated with a conductive layer before imaging with an electron microscope. FFEM is particularly valuable for studying cellular membranes, organelles, and protein complexes, allowing researchers to visualize intricate structures and interactions at the nano-scale.