What Does FKBP Stand For?

FKBP stands for FK506 Binding Protein

FKBP, or FK506 Binding Protein, refers to a family of proteins that bind to the immunosuppressive drug FK506 (tacrolimus). These proteins play a crucial role in various cellular processes, including protein folding and signal transduction. By interacting with specific receptors, FKBP influences immune responses and has implications in transplantation, autoimmune diseases, and cancer therapy. The most studied member of this family, FKBP12, is involved in the inhibition of calcineurin, a key regulator of T cell activation.