What Does GDEPT Stand For?

GDEPT stands for Gene Directed Enzyme Prodrug Therapy

GDEPT, or Gene Directed Enzyme Prodrug Therapy, is a therapeutic strategy that leverages genetic engineering to enhance the efficacy of prodrugs in cancer treatment. This approach involves the introduction of genes encoding specific enzymes into tumor cells, enabling the conversion of non-toxic prodrugs into active cytotoxic agents directly within the tumor environment. By selectively activating these prodrugs at the targeted site, GDEPT aims to maximize therapeutic effects while minimizing systemic toxicity, thereby improving treatment outcomes in cancer patients.