What Does GRK Stand For?

GRK stands for G Protein Coupled Receptor Kinase

GRK, or G Protein Coupled Receptor Kinase, refers to a family of enzymes that play a crucial role in cellular signaling processes. These kinases are responsible for phosphorylating activated G protein-coupled receptors (GPCRs), leading to their desensitization and internalization. By modulating the activity of GPCRs, GRKs help regulate various physiological functions and contribute to the pharmacological responses to numerous medications. Their function is essential in maintaining cellular homeostasis and mediating the effects of hormones and neurotransmitters.