What Does HAT Stand For?

HAT stands for Histone Acetyltransferase

HAT, or Histone Acetyltransferase, is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to specific lysine residues on histone proteins. This post-translational modification is crucial for the regulation of chromatin structure and gene expression, as it generally leads to a more relaxed chromatin state, facilitating access for transcription factors and other regulatory proteins. Dysregulation of HAT activity is associated with various diseases, including cancer.

Other Meanings for HAT