What Does HPRT Stand For?

HPRT stands for Hypoxanthine Phosphoribosyltransferase

HPRT, or Hypoxanthine Phosphoribosyltransferase, is an essential enzyme involved in the purine salvage pathway. It catalyzes the conversion of hypoxanthine and ribose-5-phosphate into inosine monophosphate, facilitating the recycling of purines and maintaining nucleotide balance within cells. Mutations in the HPRT gene can lead to severe metabolic disorders, including Lesch-Nyhan syndrome, characterized by neurological and behavioral issues.