What Does ICDH Stand For?

ICDH stands for Isocitrate Dehydrogenase

Isocitrate Dehydrogenase (ICDH) is an important enzyme in the citric acid cycle, responsible for catalyzing the oxidative decarboxylation of isocitrate to alpha-ketoglutarate. This reaction is a critical step in cellular respiration, playing a key role in energy production and metabolic processes. ICDH exists in various forms, including mitochondrial and cytoplasmic isoenzymes, and its activity is regulated by factors such as NAD and ATP levels. Dysregulation of ICDH can be linked to various metabolic disorders and cancer.