What Does PHF Stand For?
PHF stands for Paired Helical Filament
PHF, or Paired Helical Filament, refers to a structural arrangement of protein filaments characterized by their distinctive helical shape and paired formation. This structure is primarily associated with the aggregation of tau proteins in neurodegenerative diseases, particularly in Alzheimer's disease, where it plays a key role in the development of neurofibrillary tangles. PHFs contribute to the understanding of pathological protein interactions and help in the study of mechanisms underlying neurodegeneration.
Added on 14th April 2008 | Last edited on 16th June 2025 | Edit Acronym