What Does STAT Stand For?
STAT stands for Signal Transducer And Activator Of Transcription
STAT, or Signal Transducer And Activator Of Transcription, refers to a family of transcription factors that play a crucial role in mediating cellular responses to various extracellular signals, particularly cytokines and growth factors. Upon activation, STAT proteins undergo phosphorylation, dimerize, and translocate to the nucleus, where they bind to specific DNA sequences to regulate gene expression involved in processes such as immune response, cell growth, and differentiation. Their dysregulation is associated with several diseases, including cancer and autoimmune disorders, making them important targets for therapeutic intervention.
Added on 14th April 2008 | Last edited on 16th June 2025 | Edit Acronym